Antigen Processing and Recognition

This book provides a state-of-the-art review of the processing, presentation, and subsequent recognition of antigens by T cells. Topics discussed include the structure of MHC molecules, the nature and specificity of human class II molecule interactions with peptide antigens, the class II invariant chain, antigen processing and presentation by class I MHC molecules, the biology of antigen processing, and the presentation and role of accessory molecules in T cell recognition. Other chapters feature discussions about the T cell allorecognition of MHC molecules, the recognition of minor antigens, and the concept of "superantigens." Color plates demonstrate the three-dimensional structure of MHC molecules and peptide antigen interaction with MHC molecules. Diagrams illustrate antigen presentation pathways, T cell receptor-MHC interaction and accessory molecule interactions. Antigen Processing and Recognition will be a valuable addition to the libraries of students and teachers of immunology, as well as cellbiologists who are looking for a unified view of this rapidly expanding subject.McCluskey, James is the author of 'Antigen Processing and Recognition' with ISBN 9780849369322 and ISBN 0849369320.