Practical Process Research & Development

Bringing a compound to market quickly and profitably requires efficient and cost-effective processes for preparing large amounts of the target compound and intermediates. The key to rapid and successful process development is avoiding scale-up problems. However, an understanding of scale-up issues is rarely taught in academia and may take years of industrial experience to acquire. Practical Process Research & Development teaches how to anticipate and avoid these problems when processes are being scaled up from the research lab or pilot plant. The approach is pragmatic, with a minimum of theory and over 100 practical scale-up tips. Many tables and detailed reaction schemes allow the reader to identify critical processing steps quickly. This practical guide is essential reading for chemists and chemical engineers involved in industrial process research and/or process development and for anyone seeking a clearer understanding of how and why process R&D is conducted in the pharmaceutical and fine chemicals industries. KEY FEATURES · Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" · Breaks down process optimization into route, reagent, and solvent selection, development of reaction conditions, workup, crystallizations, and more · Describes how to anticipate and avoid difficulties in scaling up reactions · Discusses guidelines for the timely development of processes · Illuminates principles with examples from the recent literature · Includes over 100 tips for rapid process development · Presents guidelines for implementing and troubleshooting processes · Written by an author with over 22 years experience in process R&D in the pharmaceutical industry "... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department." --Sean T. Nugent, Searle Research & DevelopmentAnderson, Neal G. is the author of 'Practical Process Research & Development' with ISBN 9780120594757 and ISBN 0120594757.