Peptide and Protein Drug Analysis

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design.Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication.Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis- discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability- analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology- examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods- highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry- demonstrates uses of unnatural mutagenesis and combinatorial chemistry- explores mass spectrometry, protein sequence, and carbohydrate analysis- illustrates bioassays and other new functional analysis methods- surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR)- addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells- reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering- and more!Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.Reid, Ronald E. is the author of 'Peptide and Protein Drug Analysis' with ISBN 9780824778590 and ISBN 0824778596.