Glycobiology

Glycobiology covers the whole of the field, from chemistry to biology, and from pure science to industrial and medical applications. Leading researchers from around the world review the latest advances in the following areas:!U synthesis of carbohydrates and glycoconjugates !U analysis and structure !U cell biology of carbohydrates and glycoproteins!U carbohydrate binding proteins !U carbohydrate modifying enzymes !U glycobiology and medicine !U industrial glycobiologyAll chapters are short reviews written to be accessible to new entrants to the field, but with a focus on the latest research, to appeal directly to postgraduates and researchers in the glycosciences, whether in academic or industrial settings.________________________________________Provisional Contents: 1. INTRODUCTIONPreface Liz Hounsell, Birkbeck CollegeHalf a Century at the carbohydrate-protein Interface: Nathan Sharon and the development of a discipline Clare Sansom, Birkbeck CollegeGlycobiology: Discovery, diagnostics and drugs Raymond Dwek, University of Oxford2. SYNTHESIS OF CARBOHYDRATES AND GLYCOCONJUGATESChemical synthesis of carbohydrates Ben Davis, University of OxfordAminoglycosides Timor Baasov, Israel Institute of TechnologySugar-lectin interactions: Glyco-targeting with synthetic glycoconjugates Michel Monsigny, CNRS OrleansRecent developments in the synthesis and application of sialylmimetics Hans Streicher, University of Sussex3. ANALYSIS AND STRUCTUREAnalysis of N-linked carbohydrates by mass spectrometry David Harvey, University of OxfordThird dimension of the glycome David Fernig, University of LiverpoolCarbohydrate biosensors Raz Jelinek, Ben Gurion UniversityStructure and function of chondroitin and dermatan sulphates Robert Lauder, Lancaster UniversityGlycomics Ram Sasisekharan, MITFunctional analysis of N-glycans in flies and worms Jim Dennis, Mount Sinai Hospital4. CELL BIOLOGY OF CARBOHYDRATES AND GLYCOPROTEINSHeparan sulphate proteoglycans in health and disease John Gallagher, Christie Hospital ManchesterGalectins: Effective modulators of cytoskeletal organization and cellular growth Yehiel Zick, Weizmann Institute of ScienceLectins and sugars Claudine Kieda, CNRS OrleansIntracellular lectin involvement in glycoprotein maturation and quality control in the secretory pathway Gerardo Lederkremer, Tel Aviv University5. CARBOHYDRATE BINDING PROTEINSThe diversity of sialic acids and their interplay with lectins Roland Schauer, Biochemisches Institut KielStructure and Carbohydrate Specificity of Ya-Prism I fold lectinsM. Vijayan, V. Surolia and K. Sekar, Indian Institute of ScienceGalectins: Amplifiers, silencers or tuners of the inflammatory response Gabriel Rabinovich, University of Buenos AiresRecognition under stress: Selectins and integrins in immune cell recruitment Ronen Alon, Weizmann Institute of SciencePulmonary surfactant proteins: Lectins of innate immunity Yitzhak Ofek, Tel Aviv University6. CARBOHYDRATE MODIFYING ENZYMESComplex carbohydrate modifying enzymes Spencer Williams, University of MelbourneGlycosylation in development Pamela Stanley, Albert Einstein College of Medicine New YorkGlycosyltransferase structure and function Inka Brockhausen, Queen''s University, Ontario7. GLYCOBIOLOGY AND MEDICINEGalectins 1 and 3 in cancer cell differentiation, survival and progression Hans-Joachim Gabius, Ludwig-Maximillians-UniversityMucosal glycoconjugates in inflammatory bowel disease and colon cancer Jon Rhodes, University of LiverpoolGlycobiology of mucins in the human intestinal tract Anthony Corfield, Mucin Research Group, University of BristolSelectin-mediated metastasis of cancer cells Reiji Kannagi, Nagoya City UniversityGlycosphingolipids in health and disease Tony Futerman, Weizmann Institute of SciencePathogen-host Iiteractions in the human intestinal protozoan parasite, entamoeba histolytica David Mirelman, Weizmann Institute of Science8. INDUSTRIAL GLYCOBIOLOGYGlycoanalysis on a lectin array: Application to life science research and development of biopharmaceuticals Rakefet Rosenfeld, ProcogniaLectin chips and CarboDeep'a: A rapid carbohydrate fingerprinting technology and its application for the food scientists Ofer Markman, NutricogniaThe development of imino sugars as drugs Bryan Winchester, Institute of Child HealthSansom, Clare is the author of 'Glycobiology ', published 2007 under ISBN 9781904842279 and ISBN 1904842275.