Genes V

Genes V gives an integrated account of the structure and function of genes in both prokaryotic and eukaryotic organisms. It is thoroughly up-to-date with the latest thinking and research in the field. Successive editions have provided an integrated account of the whole field of modern molecular genetics and this edition continues that approach, providing a new synthesis with a much greater emphasis on how genes function in their biological context. The book begins with an introductory overview of material that the student should have encountered in previous courses. These first two chapters consider the cell as an assembly of macromolecules, reviewing the function of these molecules and how they are organized into cell organelles. There follows a detailed examination of the role and function of DNA with increased emphasis on genetic mapping in the context of human disease. The third part of the book discusses translation and has been thoroughly updated to reflect new knowledge about structure and the specificity on DNA function. A new section on cell biology follows. This brings together much information that was scattered in previous editions of the book and integrates it with new knowledge on protein transport, signal transduction, and the cell cycle. The section on gene expression has been thoroughly modernized and updated as have the two chapters which follow, one of which gives an entirely new account of gene sizes, organization and differences in eukaryotes. The book gives, for the first time, a unifying concept for eukaryotic transcription and its regulation reflecting work done since 1990. The chapter on recombination has been entirely rewritten and is followed by updated coverage of manipulations of DNA: transposons, retroviruses, and rearrangements. The book concludes with chapters examining in detail the role of genes in some of the key areas of molecular biology research, molecular immunology, development, and oncogenesis. Changes in the content of the book, which have given it greater coherence and a much more logical structure, are reflected by a new design bringing greater clarity, there are fewer tables and those that remain have been redesigned and simplified. All figures have been redrawn in a modern style using state-of-the-art graphics in full color.Lewin, Benjamin is the author of 'Genes V' with ISBN 9780198542872 and ISBN 0198542879.