Drug Testing in Vitro Breakthroughs and Trends in Cell Culture Technology

Here, expert scientists from industry and academia describe an emerging platform technology with tremendous potential. Human micro-organoid in-vitro test systems could well be the next breakthrough in overcoming two major obstacles for developing new therapeutics. Firstly, they allow the identification of the biological effects of new drugs that involve systemic interactive networks specific to humans. Secondly, they facilitate the testing of human genetic diversity and genetic predisposition. In addition, there is increased industrial interest in these test systems to comply with such regulative measures as the cosmetics directive or the European REACH program for the registration, evaluation and authorization of chemicals. This highly topical handbook is divided into four parts, the first providing an overview of emerging in-vitro culture technologies. Part II covers primary tissues and cell lines in drug screening/testing. Part III emphasizes conflicting ethical, regulatory and commercial requirements for drug testing and screening on human micro-organoids in vitro as a viable alternative to animal testing, . The final part concludes with the tremendous potential of the in-vitro drug evaluation platform technology, using human immune micro-organoids as a prime example. The book is introduced by a short foreword by Rolf Krebs, former president of the European Federation of Pharmaceutical Industries and Associations and of the International Federation of Pharmaceutical Manufacturers Associations, as well as a Member of the Board of Directors of the Chemical Industry Association. The result is essential reading for professionals dealing with drug development and testing, orchemical risk assessment.Marx, Uwe is the author of 'Drug Testing in Vitro Breakthroughs and Trends in Cell Culture Technology', published 2007 under ISBN 9783527314881 and ISBN 3527314881.