Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and Other Xenobiotics

One of the most extensively studied enzyme systems worldwide is the cytochromes P450, and this interest very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out-of-date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and other Xenobiotics deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working in the Fine Chemicals, and especially those in the Pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. The book should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level.Ioannides, Costas is the author of 'Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and Other Xenobiotics', published 2008 under ISBN 9780854042746 and ISBN 0854042741.