A Guide to the Chemical Basis of Drug Design

HISTORY OF MEDICINAL CHEMISTRY. Evolution of the Discipline. Historical Development of Medicinal Science. Systematic Drug Development and Rational Research Methods. The Crowded Years of Innovation and Expansion. RECENT RESEARCH. Antihypertensive Agents. Antiinflammatory Agents. Antiviral and Antitumor Agents. Histamine (H1 and H2) Receptor Antagonists. Drugs that Counteract the Effects of Acetylcholine. Drugs for Relief from Pain. Antihyperglycemic Agents. General Aspects of Drug Design. Molecular Modification. Quantitative Structure - Activity Analysis. Conformational Analysis. SELECTED EXAMPLES OF DRUG DESIGN. Thyroid Hormones and Thyromimetics. The D Vitamins. Peptides and Proteins. Anticoagulants. Cholinergic, Curariform, and Related Agents. Anticholinergics and Histamine-1 Receptor Antagonists. Local Anesthetics. Neuroleptic Agents. Antidepressants. Antianxiety Agents. Sedative Hypnotics and Anticonvulsants. Analgetics. Antiinflammatory Agents. Steroidal Hormones and Their Analogs. Antiinfectious Agents. Chemotherapeutic Antibacterials. Antimycobacterial Agents. Antibiotics. Antiprotozoal Agents. Anthelmintics. Antiviral and Tanineoplastic Agents. Orphan Drugs. References. Index.Burger, Alfred is the author of 'A Guide to the Chemical Basis of Drug Design', published 1983 under ISBN 9780471868286 and ISBN 0471868280.